The Institute for Specialized Medicine collaborates with nutraceutical company Restorative Remedies to select and design food supplements, herbal remedies and their combinations supporting patients with arthritis and autoimmune diseases.  Currently, the first line of professional-grade products is exclusively available for clients of the institute. The line includes remedies capable of 1) benefiting patients with gluten intolerance and other gastrointestinal problems; 2) normalizing inflammatory responses; 3) promoting muscle and nerve health; as well as 4) vitamins and 5) minerals. The offered products are manufactured at top-certified nutraceutical facilities and characterized by improved absorption capacity and optimized strength.

GASTRO-INTESTINAL HEALTH
GLUTEN BREAKING ENZYMES

GLUTEN BREAKING ENZYMES is a mixture of plant-derived high-potency enzymes capable of degrading gluten, casein and soy proteins and preserving their enzymatic activities at a broad range of pH varying from very acidic (2.0) to very alkaline (12.0) ones.  The enzymes can efficiently degrade correspondent food contaminations but cannot completely digest meals containing large amounts of the aforementioned proteins (for example, sandwich or glass of milk).

Recommended dose:
2 capsules before meal and 2 capsules after meal.

Drug interactions:
Not reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Please consult your physician if being treated for peptic ulcers.

Synergistic effect with other food supplements:
Prebiotics

INTESTINAL BALANCE

INTESTINAL BALANCE contains a natural remedy with activities against yeast, calcium undecylenate (calcium salt of a fatty acid from castor oil), anti-inflammatory herbal product berberine and antioxidant complex from green tea. This product can normalize inflammatory processes in gastrointestinal tract and suppress yeast overgrowth.

Recommended dose:
2 tablets twice a day before meals.

Drug interactions:
Not reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Unknown.

Synergistic effect with other food supplements:
Prebiotics
Probiotic

PREBIOTIC
microflora base

Prebiotics are defined as non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of beneficial bacteria in the colon and enhance gastrointestinal and systemic immune functions. PREBIOTIC microbial base™ combines chicory inulin and oligofructose, highly effective prebiotics, with the immunomodulating actions of larch arabinogalactan and purified yeast beta-glucan.

Chicory-derived inulin and oligofructose are inulin-type fructans best known for their ability to sustain increases in populations of Bifidobacterium, Lactobacillus, and Eubacterium, an important butyrate-producing species indigenous to the bowel.  In addition, inulin-type fructans promote normal colon transit times, enhance absorption of calcium and magnesium, favorably modulate lipid levels, and improve gut mucosal barrier and immune functions.

Arabinogalactan, a polysaccharide derived from the Western Larch tree, is a highly soluble dietary fiber that enhances immune function by promoting cytokine production and increasing the number of natural killer cells. Arabinogalactan is metabolized to short-chain fatty acids acetate, butyrate, and propionate and reduces ammonia production.
Beta-glucan, a glucose polysaccharide prebiotic fiber, has broad, beneficial effect on immune function through enhancement of monocytes, macrophages, and natural killer cells.

Recommended dose:
2 capsules twice a day.

Drug interactions:
Not reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Please consult your physician if being treated for peptic ulcers or ulcerative colitis.

Synergistic effect with other food supplements:
Probiotics
Berberine

PROBIOTIC
microflora essentials

Probiotics are defined as live microorganisms which when administered in adequate amounts confer a health benefit on the host. PROBIOTIC microflora essentials™ is a hypoallergenic blend of 10 probiotic species developed specifically for the maintenance of a healthy intestinal microflora. PROBIOTIC microflora essentials™ supplies beneficial probiotic organisms generally not present in modern, highly processed foods together with indigenous species whose numbers decline with age, antibiotic and other drug therapies, and stress.

Recommended dose:
2 capsules twice a day before meals.

Drug interactions:
Not reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Unknown.

Synergistic effect with other food supplements:
prebiotics
berberine

PANCREATIC DIGESTIVE ENZYMES

PANCREATIC DIGESTIVE ENZYMES utilizes porcine-derived high-potency pancreatin for reliable and consistent enzyme activity that is specific for fat, protein, and carbohydrate. Extra amounts of lipase, specific for breakdown of dietary fat, are included. Tablet disintegration is carefully controlled to quickly release contents upon reaching the small intestine, thus avoiding destruction of enzymes by gastric acid.

Recommended dose:
1 capsule three times a day with meals.

Drug interactions:
Not reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Unknown.

   
INFLAMMATION MANAGEMENT

INFLA-BALANCE
inflammatory control

INFLA-BALANCE is a synergistic combination of nine herbal remedies affecting various proinflammatory cascades including cyclooxygenase 1 and 2 (COX-1 and COX-2) mediated pathways. The herbs include turmeric root, rosemary leaf, holy basil leaf, green tea leaf, ginger root, Chinese goldenthread root, barberry root, Baikal skullcap root and polygonum root.  Each of the herbal extracts included in INFLA-BALANCE contains multiple, beneficial compounds and have documented ability to help modulate proinflammatory mediators, scavenge free radicals, and promote physiological balance in susceptible tissues in a safe and harmonious fashion.

Recommended dose:
1 capsules twice a day with food.

Drug / supplement interactions:
None reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Please consult your physician if being treated for peptic ulcers or other gastro-related conditions

Synergistic effect with other food supplements:
Feverfew
Omega-3 EPA/DHA

EVENING PRIMROSE OIL
natural source of GLA

EVENING PRIMROSE OIL is valued as a premium source of gamma-linolenic acid (GLA).  GLA is an essential fatty acid possessing anti-inflammatory activity. Each softgel contains 124 mg of biologically active GLA. Cold-pressed without hexane or other solvents.

Recommended prophylactic dose:
1 softgel a day.

Recommended therapeutic dose:
1 softgels three times a day.

Drug / supplement interactions:
None reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Uknown.

Synergistic effect with other food supplements:
Omega-3 EPA/DHA
Turmeric
Berberine
N-acetylcysteine
L-glutathione

OMEGA-3 EPA / DHA
heavy metal free

OMEGA-3 EPA/DHA is a combination of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids from cold water marine fish.  OMEGAO-3 EPA/DHA influences physiological processes regulating of inflammation, lipoprotein metabolism, brain function, and mood regulation. OMEGAO-3 EPA/DHA is molecularly distilled to ensure removal of heavy metals (mercury, lead, etc.), pesticides, and other contaminants. Each softgel supplies a guaranteed minimum amount of 270 mg EPA and 190 mg DHA. These amounts represent the actual “elemental” weight of EPA and DHA, not the higher weight of the fatty acid compound typically reported. Mixed vitamin E tocopherols maintain freshness by retarding lipid peroxidation. Each batch of softgels is analyzed by an independent testing laboratory to verify oil purity and omega-3 potency. Cholesterol-free.

Recommended prophylactic dose:
1 softgel twice a day.

Recommended therapeutic dose:
2 softgels three times a day.

Drug / supplement interactions:
None reported to our knowledge. Please consult your health care professional before taking this or any other supplements.

Contraindications:
Uknown.

Synergistic effect with other food supplements:
Evening primrose oil
Turmeric
Berberine
N-acetylcysteine
L-glutathione

TENSION AID
support for head and neck

TENSION AID is a combination of a feverfew extract with riboflavin (vitamin B2). Feverfew is a traditional medicinal herb which has been used for reducing fever, for treating headaches, arthritis and digestive problems. It is hypothesized that by inhibiting the release of serotonin and prostaglandins, feverfew limits the inflammation of blood vessels in the head and neck.  Clinical studies have shown that feverfew has a strong synergistic effect with riboflavin. In general, the remedy has a delayed onset of activity: it might take four to six weeks before it maximal effect becomes noticeable.

Recommended dose:
1 capsules twice a day.

Drug / supplement interactions:
None reported to our knowledge.  Please consult your health care professional before taking this or any other supplements.

Contraindications:
Unknown.

Synergistic effect with other food supplements:
Turmeric
Berberine

MSM
normalizes response to inflammation

MSM (methylsulfonylmethane) is a source of organic sulfur demonstrating anti-inflammatory activity. Published clinical data indicate that MSM can benefit patients with osteoarthritis. 

Recommended prophylactic dose:
1 capsule 3 times a day.

Recommended therapeutic dose:
2 capsules 3 times a day.

Drug / supplement interactions:
None reported to our knowledge.  Please consult your health care professional before taking this or any other supplements.

Contraindications:
Uknown.

Synergistic effect with other food supplements:
Turmeric

   
MUSCLE / NERVE HEALTH

CONCENTRATION AID
alpha-ketoglutaric acid

ALPHA-KETOGLUTARIC ACID is a naturally-occurring organic acid, formed primarily as part of the energy generating citric acid cycle. One of its most important functions is to detoxify brain from ammonia and nitrogen overload causing concentration problems, known as “brain fog”.
Other important functions of alpha-ketoglutaric acid include:
Support of muscle protein synthesis
Formation of carnitine, necessary for proper metabolism of fats 
Formation of a biologically active coenyzme form of vitamin B3
Support of bone collagen synthesis and maintenance of strong bones and bone density

Recommended dose:
300 mg twice a day with meals

Drug interactions:
None reported to our knowledge.  Please consult your health care professional before taking this or any other supplements.

Contraindications:
Please consult your physician if you are being treated for memory-loss or other related disease.

Synergistic effect with other food supplements:
Pyridoxal-5’-phosphate

MUSCLE ENERGY STABILIZER
malic acid

MALIC ACID is a naturally-occurring organic acid and is a part of the citric acid cycle.  Malic acid is naturally found in sour apples and other tart fruits.  One of its important functions is energy generation under both aerobic and anaerobic conditions. Therefore, this ingredient is frequently used to improve muscle fatigue.

Recommended dose:
500 mg three times a day with meals

Drug interactions:
None reported to our knowledge.  Please consult your health care professional before taking this or any other supplements.

Contraindications:
Please consult your physician if being treated for peptic ulcers or other gastro-related conditions

Synergistic effect with other food supplements:
Magnesium salts

MUSCLE ANTIOXIDANT COMPLEX
organic sources of sulfur

MUSLE ANTIOXIDANT COMPLEX consists of three natural sulfur-containing compounds important to the body's antioxidant defense mechanisms: N-acetyl-L-cysteine, L-glutathione and taurine. The production of reactive oxygen species in skeletal muscle is linked with muscle fatigue. Therefore, consumption of the sulfur containing antioxidants reduces muscle fatigue and improves performance.
N-acetylcysteine is the precursor of both the amino acid L-cysteine and glutathione. Historically it has been used as a mucous thinning agent to promote optimal respiritory function.    Currently, it is used to promote respiratory health, detoxification and the prevent free radical and oxidative damage.
L-glutathione, a tripeptide containing L-cysteine, L-glutamic acid, and glycine, protects cells from toxins and free radicals.    
Taurine is a derivative of the sulfur-containing amino acid cysteine. Taurine participates in a number of physiologic processes including regulation of neurotransmission, calcium homeostasis, regulation of glucose and lipid metabolism, blood pressure, help with stress, support of retinal function and stabilization of muscle performance.

Recommended dose:
1 capsule (850 mg) twice a day

Drug interactions:
None reported to our knowledge.  Please consult your health care professional before taking this or any other supplements.

Contraindications:
Unknown

NERVE AND MUSCLE INTEGRITY
alpha-lipoic acid

ALPHA-LIPOIC ACID, also known as thioctic acid, is a naturally occurring compound that is synthesized in small amounts by plants and animals, including humans. Alpha-lipoic acid is a strong antioxidant and an essential cofactor for several mitochondrial enzyme complexes that participate in energy production. Other important functions of alpha-lipoic acid include chelation of toxins, stimulation of L-glutathione synthesis, and improvement of glucose consumption.  In Germany, alpha-lipoic acid is widely used to help those with peripheral neuropathy.

Recommended prophylactic dose:
100 mg twice a day on empty stomach (one hour before or two hours after meal).

Recommended therapeutic dose:
300 mg twice a day (one hour before or two hours after meal).

Drug / supplement interactions:
This product can interact with Biotin.  We recommend that you avoid biotin containing supplements when taking this product.

Contraindications:
Please consult your physician before taking this product if being treated for hypoglycemia.

Synergistic effect with other food supplements:
Benfothiamine
N-acetylcysteine
L-glutathione

   
VITAMINS

MULTIVITAMINS
gluten-free
casein-free

MULTIVITAMINS contain all essential vitamins and common minerals with exception of iron. In comparison to over-the-counter vitamins, our product is characterized by enhanced antioxidant protection, broader trace element nutrition, and augmented B-vitamin support. This core foundation of essential nutrients thus provides an extra measure of nutritional protection that can be recommended for daily use. A clear, water-soluble cellulose coating protects the stability of the nutritional ingredients and makes the tablets easy to swallow. Each batch is tested using USP protocols to ensure tablet disintegration time of 45 minutes or less to help maximize nutrient bioavailability.

Recommended dose:
1 tablet twice a day.

PYRIDOXAL 5'-PHOSPHATE
active form of vitamin B6

PYRIDOXAL 5’-PHOSPHATE is the converted and easy-to-absorb derivative of vitamin B6. This phosphorylated B6 metabolite is a coenzyme in more than 50 different metabolic steps, including amino acids conversion, red blood cell and neurotransmitter production, and fatty acid metabolism.

Recommended dose:
1 capsule a day.

VITAMIN D3
active form of vitamin D

VITAMIN D3, the naturally-occurring active form of vitamin D, is supplied in high-potency amount of 1,000 I.U. per capsule for those needing to conveniently augment dietary intake. A daily vitamin D3 intake of 1,000 to 2,000 units, an amount shown to be safe and effective by clinical studies, is now advised by many experts.

Recommended dose:
1 or 2 capsules a day.

VITAMIN B12 (SUBLINGUAL)
with folic acid

VITAMIN B12 at a high concentration is included in these sublingual tablets to bypass normal absorptive mechanisms that rely on intrinsic factor. Folate complements the actions of B12 for homocysteine methylation and nervous system function. Tablets should be dissolved in the mouth.

Recommended dose:
1 tablet a day.

BENFOTIAMINE
highly absorbable
vitamin B1

BENFOTIAMINE is a fat-soluble form of thiamine (vitamin B1) with high bioavailability. Oral benfotiamine passively diffuses through the intestinal mucosa and is rapidly converted to active thiamine. Bioavailability of benfotiamine is up to 3.6 times greater than water-soluble thiamine salts and is associated with a 120-fold greater increase in the levels of metabolically active thiamine diphosphate. Benfotiamine inhibits several pathways involved in glucose-induced vascular damage and neuropathies.

Recommended dose:
1 capsule a day.

ESTER-C
buffered vitamin C

ESTER-C is a non-acidic form of vitamin C.  It is made using a proprietary, water-based manufacturing process which results in a pH neutral product that contains naturally occurring vitamin C metabolites. These metabolites activate the vitamin C molecules making it easier for the body to transport them from cell to cell for numerous health benefits.

Recommended dose:
1 or 2 capsules a day.

   
MINERALS

CALCIUM CITRATE-MALATE
organic, highly absorbable

CALCIUM CITRATE-MALATE is a readily-soluble form of calcium which is equally well-absorbed with or without food. About 40% more calcium is absorbed from calcium citrate-malate compared to calcium carbonate or milk. Taking calcium in several smaller doses throughout the day produces higher absorption than taking a larger dose all at once. Testing assures exceptionally low lead content.

Recommended dose:
2 tablets twice a day.

MAGNESIUM CHELATE
organic, highly absorabble

MAGNESIUM CHELATE is a mixture of magnesium glycinate and magnesium lysinate providing highly absorbable source of organic magnesium. Magnesium chelate is well-tolerated without gastrointestinal side effects compared to inorganic salt forms of this mineral.

Recommended dose:
1 or 2 capsules a day with meals.

ZINC CHELATE
organic, highly absorbable

ZINC CHELATE produced through a special process that completely bonds zinc to the amino acid glycine forming zinc glycinate, a well absorbed form of this essential mineral. The absorption and bioavailability of zinc chelate is much higher as compare to that of inorganic zinc sulfate.  Each capsule of zinc chelate contains 20 mg of elemental zinc.

Recommended dose:
1 capsule a day.

IRON CHELATE
organic, highly absorabble

IRON CHELATE is produced through a special process that completely bonds iron to the amino acid glycine forming ferrous bis-glycinate, a well absorbed form of this essential mineral. The absorption and bioavailability of iron chelate is much higher as compare to that of commonly used iron preparation ferrous sulfate.  Each capsule of iron chelate contains 30 mg of elemental iron.

Recommended dose:
1 or 2 capsules a day.