Platelet-Rich Plasma Therapy (PRP)


View this PRP handout to learn: how how to prepare for the procedure, what to expect during, and what to do after.


What is PRP?
PRP is an autologous therapy (meaning that the donor and recipient is the same person) that is based on injecting the platelet rich portion of a person’s blood directly into the arthritic or injured area. This catalyzes the body’s ability to repair damaged tendons, partially ruptured muscles, as well as heal bone and cartilage defects in arthritic joints.

How does PRP work?
Platelets, or thrombocytes, are small, irregularly shaped clear cell fragments (i.e. cells that do not have a nucleus containing DNA), which are derived from the fragmentation of precursor megakaryocytes.  Platelets circulate in human blood and are involved in hemostasis, leading to the formation of blood clots. The premise of PRP therapy is based on the fact that upon injection, the platelets spread over injured tissues and release various growth factors (transforming growth factor beta (TGFbeta), vascular endothelial growth factor (VEGF),  platelet-derived growth factor (PDGF), epithelial growth factor (EGF), and fibroblast growth factor (FGF))  and other biologically active molecules (for example, vitronectin and fibronectin), which stimulate regenerative and healing processes as well as bone mineralization.


Why does PRP work?
In chronic wounds and other tissues where blood supply may be low, the delivery of platelets is often impeded so adequate concentrations of growth factors, cytokines and chemokines are not released and wound healing stalls. In these cases, a patients’ own platelet rich plasma can be activated to generate a fibrin rich gel that serves as a rich source of growth factors, cytokines and chemokines to re-establish balance in the wound bed. The PRP System harnesses the patient’s natural healing processes to providing growth factors, chemokines and cytokines known to promote angiogenesis and to regulate cell growth and formation of new tissue. PRP technology restores the balance in the wound environment to transform a non-healing wound to a wound that heals naturally.


What conditions is PRP good for?
Typical indications for PRP therapy in humans include chronic tennis elbow, chronic rotator cuff syndrome of the shoulder, knee/patellar tendinitis and meniscal tears, achilles tendinitis as well as chronic low back pain and spine instability. The latest expanded indications for PRP therapy also include knee, hip and shoulder osteoarthritis and even chronic pain after joint replacement surgery.


What is the process?
PRP therapy starts with platelet separation from the whole blood via spinning/centrifugation incorporating the most advanced techniques in laser-guided platelet separation. Subsequently, PRP is harvested into a syringe for injection.  Using ultrasound guidance, the physician can precisely deliver PRP to the arthritic or injured site.


What is the technology?
We use the latest advanced techology, Angel PRP system by Cytomedix. Many platelet concentrate systems are rigid in how much whole blood they are able to process, the quantity of platelet rich plasma produced and how the clinician is able to operate the device. With the Cytomedix Angel, blood separation has more possibilities.


Watch a video of Dr. Shikhman performing the procedure

How many treatments will I need?
Depending on the nature and duration of the injury, the satisfactory healing process may require between one to six treatments.

Why is PRP beneficial?
It can provide pain relief and healing without the need for surgery and prolonged recovery time
Low-risk minimally invasive procedure
Because your own blood is used, there is no risk of a transmitting infection and a very low risk of allergic reaction


View this PRP handout to learn: how how to prepare for the procedure, what to expect during, and what to do after.

PRP Testimonial


I was in excruciating pain that brought me to tears. I couldn’t hold a fork to eat or sign my name. I couldn’t pinch or pull anything, I couldn’t put on my clothes or hold items. The smaller the object, the worse the pain.

I started out with physical therapy, but did not get the results I wanted—there was no noticeable improvement. I was totally non-functioning and PRP sounded like the best treatment. I had 3 treatments on my right hand and 5 on my left as it was always worse than my right.

Did you experience any side effects from PRP?
It was painful for 3 days. The first 1-2 days I would just sit still and not do anything. By day 3 I was feeling better, doing more for myself. By day 4 I was out and about.

After my first treatment I felt about 10% better, after the second it was up to 30%, after the third it was up to 80%. PRP is the first thing I’ve ever experienced where there was such a big improvement between treatments.

Would you consider PRP a success?
YES! I am getting the procedure done on my knees as well. Dr. Shikhman really goes above and beyond to see what what the cause is and treats it appropriately—I call it my miracle treatment by a genius doctor.