Adult (non-embryonic) mesenchymal stem cells are undifferentiated cells that have the ability to replace dying cells and regenerate damaged tissue. These special cells seek out areas of injury, disease, and destruction. Once there, they are capable of regenerating healthy cells and accelerating the natural healing process.


There is increasing evidence of using stem cells to treat autoimmune diseases, restore joint function, as well as an anti-aging therapy.


Mesenchymal stem cell therapy is preferred over the traditionally used embryonic stem cells and induced pluripotent stem cells because unlike the mesenchymal stem cell, they have the potential to form tumors.


At IFSMED our therapy uses exosomes excreted from msenchymal stem cells derived from the umbilical cord, not the actual stem cells, as research as shown greater beneficial outcomes from exosomes over stem cells with minimal risk.


Exosomes are membrane-enclosed nanovesicles that are facilitators of cell-to-cell communication. They facilitate the exchange of biological information between different cell types. They travel to the target area, which are then taken up by the targetís cells to facilitate healing.


Exosomes possess a strong regenerative potential and can normalize various pathological and inflammatory processes in chronic ailments. In addition, stem cell-derived exosomes are frequently used as a part of anti-aging therapy.


Beneficial uses of mesenchymal stem cell exosomes include but are not limited to:
  • chronic inflammatory and autoimmune diseases chronic fatigue syndrome
  • neurodegenerative diseases including Parkinson disease, multiple sclerosis, stroke, chronic demyelinating inflammatory neuropathies etc (exosomes penetrate through the blood brain barrier)
  • arthritis
  • acute and chronic tendinitis and tendinosis
  • muscle fatigue and muscle weakness
  • coronary artery disease and congestive heart failure
  • chronic hepatitis and other liver diseases
  • chronic kidney diseases

 

Q: What is the source of stem cell-derived exosomes? Exosomes used in our clinic are obtained from human umbilical cord stem cells. Prior to use, the donated cords are extensively tested for a number of viruses. Exosomes are produced in a FDA registered tissue facility that follows cGMP production procedures and holds both ISO 9001 and ISO 13485 quality control certification. The production of exosomes is regulated as a 351 tissue product by the Food and Drug Administration.

 

Q: How are exosomes administered?
For systemic illnesses and as a part of anti-aging therapy, exosomes are administered intravenously. As a part of joint regenerative therapy, exosomes are administered via intraarticular (joint) injections.

 

Q: How soon after administration of exosomes can a person can expect to see the benefits?
Every individual is different, but two key determinants for success are the severity of your condition and your body’s response to exosome therapy. Typically, early benefits of therapy are observed in 3-4 months. However, it is not uncommon, to see the benefits after 9 to 12 months.

 

Q: What Can I Expect After the Procedure? Are there any side effects?
Exosome transplantation is usually done on an outpatient basis; most patients should expect to walk out of the clinic without any major pain or problems. Generally speaking, aside from the initial pain at the injection site, the patient will not experience any discomfort. Less than 10% of (mostly lumbar puncture) patients have developed a minor fever, headache, nausea or vomiting. However, these side effects have never lasted more than three days and usually resolve within 24 hours. No long term negative side effects have been reported.

 

Q: When Can I Resume Physical Activity?
For the procedure to have the best chance of lasting benefit, we strongly recommend:
• Refraining from anti-inflammatory medication
• Resting for the first 24–48 hours, but do not lie sedentary
• Cardio is allowed after 3–4 weeks
• After four weeks, weight lifting and running are permitted

 

Q: Why are exosomes safer than stem cells?
Stem cells can proliferate and establish in the recipient’s body possessing a certain risk of undesirable complications such as new tumor growth. Exosomes do not proliferate but rather transfer valuable biological signals to the recipient’s tissues and facilitate the normalization of various pathological processes.

 

Q: How do exosomes benefit the inflammatory processes?
Stem cell-derived exosomes induce high levels of anti-inflammatory cytokines, in contrast to decreased levels of pro-inflammatory molecules. In addition, they can also inhibit abnormal macrophage activation. The macrophage is a large white blood cell that is an integral part of our immune system. Its job is to locate microscopic foreign bodies and 'eat' them. However, disproportional macrophage activation can induce undesirable inflammatory processes.

 

Q: How does exosome therapy benefit patients with chronic infections and autoimmune diseases?
Chronic infections have a lot in common with autoimmune diseases, including dysregulated immune response incapable of protecting our body from intruders (bacteria, viruses, molds etc) while attacking its own tissues and organs thus causing significant structural damage. One of the key mechanisms controlling the direction of immune responses is a balance between specific immune cells involved in protection vs autoimmune responses, the Th17/Treg ratio. This ratio is significantly abnormal in patients with both chronic infections and autoimmune diseases. Exosomes from mesenchymal stem cells normalize this ratio and bring the deviant immune response back to normal.

 

Q: How can exosomes benefit musculoskeletal disorders?
Experimental data show that stem cell-derived exosomes stimulate bone growth and skeletal muscle regeneration by directing the stem cells specifically into muscle and bone cell precursors.

 

Q: How can exosomes benefit neurodegenerative diseases?
They penetrate the blood-brain barrier and stimulate neuronal differentiation, neuronal growth, and suppress inflammatory processes within the brain tissue.





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