RheumaNat (iporuru)

gluten free iporuru

Testimonial: "Over anything else that I have tried, RheumaNat has provided me with the most relief. Within a few days I noticed a difference! I am able to be active again and participate in life with my family. I can really tell when I skip taking it."



Iporuru (Alchornea castaneifolia) is a medicinal plant native to Amazon Rainforest. Traditionally, iporuru has been taken to control muscle pain and joint pain, headaches as well as toothache. In addition, iporuru is widely used as an effective aphrodisiac and geriatric tonic for males, for balancing blood sugar levels and to treat parasitic, viral and microbial infections. The anti-inflammatory properties of iporuru are attributed to a group of alkaloids, including one called alchorneine. Basic research demonstrated that the anti-inflammatory activity of iporuru relies on its ability to inhibit cyclooxigenase (COX) enzymes responsible for mediating of inflammation. In contrast to pharmacological drugs possessing COX inhibitory activity/ NSAIDs (ibuprofen, naproxen, diclophenac etc), iporuru does not cause but accelerate healing of gastric and duodenal ulcers.

Potential indications for use of iporuru in humans include:

>Potential side effects:

Potential drug interactions:


Complementary natural products:

Contents: 100 Vcaps

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Dosage Information

RheumaNat is a 4 times concentrated iporuru extract. The recommended daily dose of Rheumanat varies from 500 to 2000 mg twice a day taken after meals.

Selected references:

Ebi, G. C. “Antimicrobial activities of Alchornea cordifolia.” Fitoterapia. 2001; 72(1): 69-72.

Hiruma-Lima, C. A., et al. “Antiulcerogenic activity of Alchornea castaneifolia: Effects on somatostatin, gastrin and prostaglandin.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 215-24.

Kouakou-Siransy, G., et al. "Effects of Alchornea cordifolia on elastase and superoxide anion produced by human neutrophils." Pharm Biol. 2010 Feb;48(2):128-33.

Macrae, W. D., et al. “Studies on the pharmacological activity of Amazonian Euphorbiaceae.” J. Ethnopharmacol. 1988; 22(2): 143–72.

Manga, H., et al. "Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg." J Ethnopharmacol. 2008 Jan 4;115(1):25-9.

Manga, H.M., et al. “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae).” J. Ethnopharmacol. 2004 Jun; 92(2-3): 209-14.

Osadebe, P. O., et al. “Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves.” J. Ethnopharmacol. 2003 Nov; 89(1):19-24.

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