gluten free butterbur feverfew blend

Butterbur, also known as Petasites hybridus, is a perennial shrub growing throughout Europe, certain parts of Asia and North America that has been used for centuries as a medicinal plant to treat headaches and neck pain.


The main biologically active ingredients of butterbur are sesquiterpenes, petasin and isopetasin. Petasin possesses anti-spasmodic properties that help to reduce spasms in blood vessel’s smooth muscles. It also inhibits synthesis of leukotrienes, potent pro-inflammatory agents causing bronchial spasms in those with asthma. The second active constituent, isopetasin, reduces inflammation via changes of prostaglandin metabolism. Both ingredients have an unusually high affinity toward cerebral blood vessels.


Feverfew, also known as Tanacetum parthenium, is a member of the sunflower family that has been used for centuries as a medicinal plant to treat headaches, arthritis and fevers.


The main biologically active ingredients in feverfew are the sesquiterpene lactones, the principal one being parthenolide. Parthenolide possesses anti-spasmodic activity and helps relieve spasms in smooth muscle tissue. It also expresses anti-inflammatory activity, inhibits platelets aggregation, suppresses histamine release and inhibits cancer cell growth.


The extracts from butterbur and feverfew express strong synergistic activities.


Potential side effects:

Potential drug interactions:

Relative contraindications:


Contents: 60 VCaps


Dosage information:

The recommended dose of the butterbur/feverfew blend is 1 to 2 capsules twice a day. This remedy does not work fast. It takes 4 to 7 days before you notice benefits. Those exceeding the recommended doses must do so under the supervision of their physician due to the increased risk of potential side effects.

The product is intended for a long-term use. Do not stop consumption of butterbur/feverfew blend abruptly if taken for over 2 months. This can result in withdrawal symptoms manifesting as generalized muscle tenderness, joint pain and nausea.


Contains no: sugar, salt, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives. Vegetarian/Vegan product.


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Selected references:

Danesch UC. Petasites hybridus (Butterbur root) extract in the treatment of asthma–an open trial. Altern Med Rev. 2004;9(1):54-62.


Grossman W, Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Altern Med Rev. 2001;6(3):303-10.


Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol. 2001 Aug;8(8):759-66.


Lee DK, Gray RD, Robb FM, et al. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy. 2004;34(4):646-9.


Pareek A, Suthar M, Rathore GS, Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacogn Rev. 2011 Jan;5(9):103-10.


Taylor FR. Nutraceuticals and headache: the biological basis. Headache. 2011 Mar;51(3):484-501. doi: 10.1111/j.1526-4610.2011.01847.x.




These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

All information contained on this website is intended for informational and educational purposes only, and is not intended nor suited to be a replacement or substitute for professional medical treatment or for professional medical advice relative to a specific medical question or condition.

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