Selected Publications

1. Shikhman AR, Brinson DC, Valbracht J, Lotz MK.  Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes. Osteoarthritis Cartilage. 2009 Aug 17(8):1022-8.
2. Lemon S, Imbesi S., Shikhman A.R. Salivary gland imaging in Sjogren’s syndrome. Future Rheumatology, 2007 2(1):83-92.
3. Shikhman A.R. Glucosamine and osteoarthritis. Future Rheumatology, 2006 1(1):67-78.
4. Shikhman A.R., Amiel D., D'Lima D., Hwang S.B., Hu C., Xu A., Hashimoto S., Kobayashi K., Sasho T., Lotz M.K. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis, 2005 Jan;64(1):89-94.
5. Liu J., Numa M.M., Liu H., Huang S.J., Sears P., Shikhman A.R., Wong C.H. Synthesis and high-throughput screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. J Org Chem.Ann Rheum Dis. 2004 Sep 17;69(19):6273-83.
6. Shikhman A.R., Brinson D.C., Lotz M.K. Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses. Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E980-5.
7. Kuhn K., Shikhman A.R., Lotz M. Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis. J Cell Physiol. 2003 Dec;197(3):379-87.
8. Komuro H, Olee T, Kuhn K, Quach J, Brinson DC, Shikhman A, Valbracht J, Creighton-Achermann L, Lotz M. The osteoprotegerin/receptor activator of nuclear factor kappaB/receptor activator of nuclear factor kappaB ligand system in cartilage. Arthritis Rheum 2001 Dec;44(12):2768-76.
9. Shikhman A.R., Brinson D., Valbracht J., Lotz M. Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol 2001 Dec 15;167(12):7001-8.
10. Liu J., Shikhman A.R., Lotz M.K., Wong C. Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis. Chem Biol. 2001 Jul;8(7):701-11.
11. Shikhman A.R., Kuhn K., Alaaeddine N., Brinson D.C., Lotz M. N-acetylglucosamine prevents IL-1beta-mediated activation of human chondrocytes. J Immunol. 2001 Apr 15;166(8):5155-60.
12. Shikhman A.R., Brinson D.C., Lotz M. Profile of glycosaminoglycan-degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation. Arthritis Rheum 2000 Jun; 43(6):1307-14.
13. Greenspan N.S., Pinilla C., Shikhman A.R. Peptide mimicry of streptococcal group A carbohydrate. In: Molecular Mimicry, Microbes, and Autoimmunity. Ed. By M.W. Cunningham and R.S. Fujinami, 2000:83-94.
14. DeMarco P.J., Schulman S., Shikhman A.R. Therapies for ulcers associated with nonsteroidal antiinflammatory drugs [letter to the editor]. NEJM 1998 July 30; 339(5):350.
15. Adderson E.E., Shikhman A.R., Ward K.E., Cunningham M.W. Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: Human anti-N-acetylglucosamine/anti-myosin antibody V region genes. J Immunol 1998 Aug 15;161(4):2020-31.
16. Shikhman A.R., Cunningham M.W. Trick and treat: toward peptide mimic vaccines [news; comment]. Nature Biotechnol 1997 Jun;15(6):512-3.
17. Cherkasov V.L., Briko N.I., Shikhman A.R., Anokhina G.I. Clinical significance of determination of the discrete group A streptococcal antigens and corresponding antibodies in the blood of erysipelas patients. Klin Med (Mosk) 1995;73(4):97-8.
18. Shikhman A.R., Cunningham M.W., Greenspan N.S. Cytokeratin peptide SFGSGFGGGY mimics N-acetyl-beta-D-glucosamine in reaction with antibodies and lectins, and induces in vivo anti-carbohydrate antibody response. J Immunol 1994 Dec 15;153(12):5593-606.
19. Shikhman A.R., Cunningham M.W. Immunological mimicry between N-acetyl-beta-D-glucosamine and cytokeratin peptides. Evidence for a microbially driven anti-keratin antibody response. J Immunol 1994 May 1;152(9):4375-87.
20. Shikhman A.R., Cunningham M.W., Greenspan N.S. A subset of mouse monoclonal antibodies cross-reactive with cytoskeletal proteins and group A streptococcal M proteins recognizes N-acetyl-beta-D-glucosamine. J Immunol 1993 Oct 1;151(7):3902-13.
21. Cooper L.J., Shikhman A.R., Kangisser D., Glass D.D., Cunningham M.W., Greenspan N.S. Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains. J Immunol 1993 Mar 15;150(6):2231-42.
22. Blinnikova E.I., Shikhman A.R. Biochemical and immunochemical analysis of protein components isolated from group A streptococcal cell walls by a sparing chemical method. Zh Mikrobiol Epidemiol Immunobiol 1992;(11-12):2-5.
23. Molchanova T.O., Dynga L.O., Shikhman A.R. Streptococcal group A cell walls low-molecular-weight protein devoid of serological type-specificity. Zh Mikrobiol Epidemiol Immunobiol 1991 Feb;(2):16-20.
24. Shmakova Z.F., Kuznetsov V.D., Briko N.I., Shikhman A.R. Immunological study of lysates from cell walls of group A Streptococcus. Antibiot Khimioter 1991 Aug;36(8):28-31.
25. Bitko S.A., Dynga L.O., Shikhman A.R. Modification of the cell wall proteins in group A streptococci type M 29 by a spermidine-contained culture medium. Zh Mikrobiol Epidemiol Immunobiol 1991 Feb;(2):4-7.
26. Briko N.I., Zhukov V.V., Dynga L.O., Smirnova M.N., Kondrakova O.A., Serna F.R., Shikhman A.R., Eshchina A.S. Pharyngeal beta-hemolytic streptococcal carrier state among blood donors. Zh Mikrobiol Epidemiol Immunobiol 1991 Jan;(1):24-7.
27. Molchanova T.O., Briko N.I., Shikhman A.R. IgM, IgG, IgA and total antibody levels against low-molecular-weight cell-wall protein of Streptococcus group A without type-specificity in sera from patients with streptococcal infection. Zh Mikrobiol Epidemiol Immunobiol 1990 Nov;(11):21-6.
28. Bitko S.A., Briko N.I., Shmakova Z.F., Shikhman A.R., Dynga L.O. Physicochemical and biochemical characteristics of cell walls from M+ and M- variants of Streptococcus group A type 29. Zh Mikrobiol Epidemiol Immunobiol 1990 Apr;(4):3-7.
29. Shikhman A.R., Briko N.I., Cherniakova A.M. Persistence and biodegradation of group A streptococcal cell walls in the light of immunopathogenesis of nonsuppurative poststreptococcal diseases. Zh Mikrobiol Epidemiol Immunobiol 1990 Feb;(2):74-80.
30. Shikhman A.R., Briko N.I., Shmidt E.I., Cherniakova A.M. Immunoenzymatic assay as a tool for analysis of persistence and biodegradation of group A streptococcal cell wall antigens in patients with rheumatism. Vestn Akad Med Nauk SSSR 1989;(6):46-9.
31. Beliakov V.D., Shikhman A.R., Briko N.I. Clinical and laboratory diagnosis of streptococcal infection. Vestn Akad Med Nauk SSSR 1989;(11):22-8.
32. Beliakov V.D., Shikhman A.R., Bogoiavlenskii S.Yu., Briko N.I. Epidemiologic aspects of the laboratory diagnostics of streptococcal infections. Vestn Akad Med Nauk SSSR 1989;(6):39-46.
33. Briko N.I., Shikhman A.R., Grushchinskaia I.A., Shmidt E.I. Secretory and systemic humoral immune responses to streptococcal group A polysaccharide in patients with rheumatism. Vestn Akad Med Nauk SSSR 1989;(6):37-8.
34. Shikhman A.R., Briko N.I., Cherkasov V.L., Anokhina G.I. ELISA with capture for determination of unmasked antigenic determinants of streptococcal group-specific A polysaccharide within the circulating immune complexes isolated from patients with erysipelas. Lab Delo 1988;(4):64-6.
35. Cherniakova A.M., Briko N.I., Shmakova Z.F., Shikhman A.R. Determination of streptococcal group-specific A-polysaccharide by ELISA: Effect of microbial cell wall degradation on the test results. Lab Delo 1988;(4):18-22.
36. Dubinin A.V., Babin V.N., Shikhman A.R., Kirkin B.V., Raevskii P.M. Nonspecific ulcerative colitis: triggering factors and disease progression. An attempt to establish a theoretical model of the pathologic process. Klin Med (Mosk) 1987 Jul;65(7):140-4.
37. Shikhman A.R., Savel'ev E.P., Kondrakova O.A., Nikolaeva L.V. Immunochemical analysis of epitopes recognized by antibodies to group A streptococcal ribosomes. Zh Mikrobiol Epidemiol Immunobiol 1986 Feb;(2):73-6.
38. Shikhman A.R., Savel'ev E.P., Kondrakova O.A., Vul'fovich Yu.V., Nikolaeva L.V. Anti-myocardial antibodies and anti-immunoglobulins in hyperimmune sera against ribosomes and cell wall surface antigens isolated from microbial variants of Streptococcus group A. Vestn Akad Med Nauk SSSR 1986;(7):35-9.
39. Shikhman A.R., Savel'ev E.P., Nikolaeva L.V., Cherkasov V.L., Anokhina G.I. Determination of antibodies against ribosomes and cell wall components, and detection of circulating antigens of group A Streptococcus in patients with erysipelas. Zh Mikrobiol Epidemiol Immunobiol 1986 Dec;(12):91-5.
40. Shikhman A.R. Utilization of ELISA in the analysis of antigenic determinants recognized by antibodies against group A streptococcal ribosomes. Zh Mikrobiol Epidemiol Immunobiol 1985 Jul;(7):52-5.
41. Shikhman A.R., Blinnikova E.I., Dzantiev B.B., Kondrakova O.A., Nikolaeva L.V. Identification of cell wall antigenic determinants in ribosomal preparations of Streptococcus group A. Zh Mikrobiol Epidemiol Immunobiol 1985 Apr;(4):15-9.
42. Shikhman A.R., Lebedev K.A. Creation of a subcutaneous artificial cavity with a pocket for collecting macrophages. Patol Fiziol Eksp Ter 1981 Sep-Oct;(5):75-6.
43. Shikhman A.R., Dil'man V.M., Lebedev K.A. Inhibiting effect of phenformin (phenethyl biguanide) on the growth of Ehrlich carcinoma. Vopr Onkol 1981;27(2):67-9.

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